Inclusion Criteria:

1. Males or females, ≥ 18 years of age
2. Part 1: documented B cell NHL (any subtype except Burkitt lymphoma, Waldenström macroglobulinemia, chronic lymphocytic leukemia); previously confirmed CD19-positive if feasible
3. Part 2: documented B cell NHL (subtypes to be determined); confirmed CD19-positive; possible expansion cohorts may include:
   1. Diffuse large B cell lymphoma (including germinal center B cell type, activated B cell type)
   2. Follicular lymphoma (including duodenal-type follicular lymphoma)
   3. Mantle cell lymphoma
   4. B cell lymphomas not specified
4. If B cell NHL subtype likely to have bone marrow involvement must be willing to undergo bone marrow biopsy in the event of an on-study complete response to confirm response
5. NHL that is relapsed, refractory to, or intolerant of existing therapy(ies) with known curative potential, or for which no standard therapy is available; must have received at least 2 prior lines of systemic therapy
6. Must be in need of systemic treatment and not require immediate cytoreductive therapy
7. Part 1: measurable or non-measurable disease
8. Part 2: measurable disease according to The Revised Criteria/Lugano Classification
9. Part 1: screening tumor biopsy requested, but optional; Part 2: patient must agree to screening tumor biopsy
10. ECOG performance status 0 or 1; anticipated life expectancy ≥ 10 weeks
11. Women of childbearing potential and fertile men agreeing to use two effective methods of contraception (including a highly effective method of contraception); women beginning 2 weeks prior to the first dose, men beginning prior to the first dose, and both continuing until 6 months after the last dose of study drug; male patients must also agree to refrain from sperm donation during this period.
12. Ability to understand and give written informed consent

Exclusion Criteria:

1. Women who are pregnant or intending to become pregnant before, during, or within 6 months after the last dose of study drug; women who are breastfeeding.
2. Central nervous system (CNS) lymphoma, leptomeningeal infiltration, or spinal cord compression not controlled by prior surgery or radiotherapy; symptoms suggesting CNS involvement
3. Part 2: History of another malignancy within 2 years, with the exception of:
   1. Treated, non-melanoma skin cancers
   2. Treated carcinoma in situ (e.g., breast, cervix)
   3. Controlled, superficial carcinoma of the urinary bladder
   4. T1a or b prostate carcinoma treated according to standard of care, with PSA within normal limits
   5. Papillary thyroid carcinoma Stage I treated surgically for cure
4. Any of the following hematologic abnormalities at baseline (transfusion allowed > 5 days previous):
   1. Hemoglobin < 8.0 g/dL
   2. Absolute neutrophil count < 1,000 per mm3
   3. Platelet count < 75,000 per mm3
5. Any of the following laboratory abnormalities at baseline:
   1. Total bilirubin > 1.5 × upper limit of normal (ULN); > 3 × ULN if with Gilbert’s Syndrome
   2. AST or ALT > 3 × ULN; > 5 × ULN if due to hepatic involvement by tumor
   3. Estimated GFR ≤ 60 mL/min corrected for BSA
   4. Albuminuria defined as urine albumin to creatinine ratio < 30 mg/g or < 3 mg/mmol) by spot urine albumin
6. Any of the following coagulation parameter abnormalities at baseline unless on a stable dose of anticoagulant therapy for a prior thrombotic event:
   1. PT or INR > 1.5 × ULN; > 3× ULN if anticoagulated)
   2. PTT > 1.5 × ULN; > 3× ULN if anticoagulated
7. Patients with:
   1. Active thrombosis, or a history of deep vein thrombosis or pulmonary embolism, within 4 weeks unless adequately treated and stable
   2. Active uncontrolled bleeding or a known bleeding diathesis
   3. Significant cardiovascular disease or condition, including:
   4. Congestive heart failure or angina pectoris requiring therapy
   5. Ventricular arrhythmia requiring therapy or other uncontrolled arrhythmia
   6. Severe conduction disturbance (e.g., 3rd degree heart block)
   7. QTc interval ≥ 480 milliseconds
   8. Left ventricular ejection fraction below the lower limit of normal or < 50% by MUGA scan or echocardiogram
   9. Class III or IV cardiovascular disease according to the New York Heart Association Functional Classification
   10. History of acute coronary syndromes (e.g., MI, unstable angina), coronary angioplasty, stenting, or bypass within 6 months
8. Significant liver disease, including:
   1. Non-infectious hepatitis
   2. Hepatic cirrhosis (Child-Pugh Class C)
9. Significant pulmonary disease or condition, including:
   1. Significant symptomatic COPD, as assessed by the Investigator
   2. History or any current evidence on imaging studies of interstitial lung disease, pulmonary fibrosis
   3. History of pulmonary inflammatory disease, pneumonitis, ARDS
   4. History of pneumonia within 6 months
10. Significant corneal disease or condition, including history of or current evidence of keratitis
11. Known HIV infection or AIDS
12. Active hepatitis B virus or hepatitis C virus infection
13. Any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever > 38ºC within 2 weeks
14. Unresolved Grade > 1 AE associated with any prior antineoplastic therapy (except persistent Grade 2 alopecia, peripheral neuropathy, decreased hemoglobin, neutropenia, lymphopenia, hypomagnesemia, and/or endocrine end-organ failure being adequately managed by HRT)
15. Known or suspected hypersensitivity to any of the excipients of formulated study drug
16. Inadequate recovery from a surgical procedure, or a major surgical procedure within 4 weeks
17. Any other serious, life-threatening, or unstable preexisting medical condition, including significant organ system dysfunction, or clinically significant laboratory abnormality(ies)
18. A psychiatric disorder or altered mental status that would preclude understanding of the informed consent process

Drugs and Other Treatments to be Excluded:

1. Receipt of:
   1. Any CD19-targeted therapy within 3 months
   2. Any tumor vaccine within 6 weeks (must have progressed if previously received)
2. Prior autologous/allogeneic CAR-T therapy if known to be CD19-negative after
3. Any other antineoplastic agent for the primary malignancy without delayed toxicity within 4 weeks or 5 plasma half-lives, whichever is shortest (except nitrosoureas and mitomycin C within 6 weeks)
4. Any other investigational treatments within 4 weeks
5. Drugs known to impair renal function, including:
   1. NSAIDS within 3 days
   2. Aminoglycoside antibiotics, amphotericin B, etc. within 1 week
   3. Bisphosphonates within 1 month
   4. Autologous hematopoietic stem cell transplantation (HSCT) within 3 months
6. Allogeneic HSCT within 6 months, or:
   1. If receiving immunosuppression
   2. If with active evidence of GVHD
7. Radiotherapy:
   1. To target lesions within 4 weeks unless progression of the lesion has been documented
   2. To non-target lesions within 1 week
8. Live/live-attenuated vaccines against infectious diseases within 4 weeks
9. Immunosuppressive or systemic glucocorticoid therapy (> 10 mg prednisone daily or equivalent) within 2 weeks
10. Prophylactic use of hematopoietic growth factors within 1 week