Research Brought to Life

Clinical trials are the most important tool we have for improving the survival of patients with cancer. You should discuss with your doctor whether a clinical trial is available and appropriate for you.

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PiNACLE | LYL314-101

PiNACLE | LYL314-101 Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma Disease Relapsed Non-Hodgkin Lymphoma Refractory Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma Large B-cell Lymphoma SummaryThis is a Phase 1/2, multi-center,…
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TRIlogy-4

TRIlogy-4 A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma (TRIlogy-4) Disease Multiple Myeloma SummaryThe purpose of this study…
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MOONSHOT (CLL11)

MOONSHOT (CLL11) CLL11 – A study to evaluate the efficacy of Epcoritamab consolidation in high genomic risk and Measurable Residual Disease (MRD)-positive Chronic Lymphocytic Leukaemia (CLL) patients after first-line venetoclax…
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EMN39

EMN39 A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant Disease Multiple…
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AMLM30 (EVOLVE II)

AMLM30 (EVOLVE II) ALLG AMLM30/EVOLVE II: Randomised study to assess revumenib in combination with azacitidine + venetoclax in adult patients with newly diagnosed NPM1-mutated or KMT2A-rearranged Acute Myeloid Leukaemia (AML)…
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SNDX-5613-0710

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation (REVEAL-ND NPM1) The purpose of this study is to assess if…
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PLATFORMPACAN1001

PLATFORMPACAN1001 A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring Disease Leukemia, Myeloid, Acute Leukemia, Lymphocytic, Chronic, B-Cell Lymphoma, Non-Hodgkin Myelodysplastic Syndromes Neoplasms Solid Tumor, Adult Prostatic Neoplasms,…
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AMLM28 (ADAPT)

AMLM28 (ADAPT) AMLM28 Platform Trial – Achieving Durable remissions via Adaptive Pro-survival Targeting in Acute Myeloid Leukaemia (AML) (ADAPT) DiseaseLeukaemia – Acute leukaemia SummaryThis platform trial will initially enrol patients…
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ALPHA3 ALLO-501A-202

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL (ALPHA3) A Randomized, Open-label Study Evaluating the Efficacy and Safety of Cemacabtagene Ansegedleucel in Participants With Minimal Residual Disease…
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SOUNDTRACK-C1

Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV) (SOUNDTRACK-C1) The purpose of this study is to evaluate…
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J6N-MC-JUCA

J6N-MC-JUCA A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 ) (BAF_FRontier-1) Disease Lymphoma, Non-Hodgkin B-cell Lymphoma Lymphoma, Large B-Cell, Diffuse Lymphoma, Follicular Lymphoma, B-cell Marginal Zone…
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INCA036978-101

INCA036978-101 Study of INCA036978 in Participants With Myeloproliferative Neoplasms Disease Myeloproliferative Neoplasms SummaryThis study will be conducted to determine the safety, tolerability, dose-limiting toxicity (DLT)s, and maximum tolerated dose (MTD)…
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DISC-0974-102

DISC-0974-102 Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia Disease Myelofibrosis; Anemia Anemia Myelofibrosis Myelofibrosis Due to and Following Polycythemia Vera Primary Myelofibrosis Post-essential Thrombocythemia Myelofibrosis…
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MagnetisMM-32 (Closed)

MagnetisMM-32 MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With…
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MDX-2003-101

MDX-2003-101 A Phase 1/2 Clinical Study Evaluating MDX2003 in Participants With Relapsed, Progressive, or Refractory B-Cell Malignancies Disease Lymphoma Waldenström Macroglobulinemia (WM) DLBCL – Diffuse Large B Cell Lymphoma PMBCL…
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INCA035784-101

INCA035784-101 A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms Disease Myeloproliferative Neoplasms SummaryThis study is being conducted to evaluate the safety and tolerability of INCA035784 in participants with…
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M24-555

M24-555 Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants…
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ZEPFHR (Closed)

ZEPFHR-MM A Centralized Platform study for Functional High Risk Multiple Myeloma Disease Multiple Myeloma SummaryThe purpose of this platform study is to assess the efficacy of different novel treatments/ combinations…
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SOUNDTRACK-E

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies (Soundtrack-E) A Phase I/II Open-Label Multi-Centre Master Protocol to Evaluate the Safety and Efficacy…
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QuANTUM-Wild (Closed)

QuANTUM-Wild This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute…
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TLN-121-2501

TLN-121-2501 TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas Disease Lymphoma Lymphoma, Non Hodgkin SummaryThe primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of…
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J2N-MC-JZNY

J2N-MC-JZNY A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/​Refractory Mantle Cell Lymphoma Disease Chronic Lymphocytic Leukemia Non-Hodgkin…
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PTX-100-02-2024

BGB-16673-304 A Phase 2 Study of PTX 100 in Patients With Relapsed/​Refractory CTCL Disease Cutaneous T-Cell Lymphoma (CTCL) SummaryThis is an open-label, phase 2 randomized study to evaluate the efficacy, safety, pharmacokinetics (PK)…
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BGB-16673-304

BGB-16673-304 A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/​Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Disease Chronic Lymphocytic Leukemia Small…
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AMLM22/D4

AMLM22/D4 The International AML Platform Consortium (IAPC) trial – is a randomised, 2-arm trial that will investigate the efficacy of oral Azacitidine combined with an allogeneic dendritic cell vaccine vididencel,…
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iMMagine-3 (Closed)

iMMagine-3 A Phase 3, Randomized, Open-Label Study to Compare the Efficacy and Safety of Anitocabtagene Autoleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Multiple Myeloma Disease Multiple Myeloma…
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HD11 (Closed)

HD11 A Randomized Phase II Study of Pembrolizumab and Brentuximab Vedotin Versus GDP, Followed by High Dose Chemotherapy and Autologous Stem Cell Transplantation for Relapsed/Refractory Classical Hodgkin Lymphoma DiseaseHodgkin Lymphoma SummaryTreatment given to…
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PyramIDH

PyramIDH A Phase 3, Multicenter, Open Label, Randomized, Non-comparative Two-arm Study of Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Adult Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)…
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90189892AML1001

90189892AML1001 A Phase 1, First-in-Human, Dose Escalation Study of JNJ-90189892 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms. DiseaseLeukemia, Myeloid, Acute Myelodysplastic Neoplasms Summary The purpose of Part…
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BGB-11417-302

BGB-11417-302 A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/​Refractory Mantle Cell Lymphoma Disease Mantle Cell Lymphoma B…
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CPI-818-004

CPI-818-004 Soquelitinib vs Standard of Care in Participants With Relapsed/​Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma Disease Peripheral T-Cell Lymphoma, Not…
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BGB-21447-102

BGB-21447-102 BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/​Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer Disease Hormone-receptor-positive Breast Cancer HER2-negative Breast Cancer Metastatic Breast Cancer…
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SNDX-5613-0708 (Closed)

A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and clinical activity of SNDX-5613 in combination…
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SC291-101 (Closed)

SC291-101 SC291-101 is a Phase 1 study to evaluate SC291 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers. Disease Non Hodgkin Lymphoma Chronic Lymphocytic Leukemia SummaryThis is…
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BGB-11417-108

BGB-11417-108 The purpose of this study is to establish the safety of novel dosing and ramp-up schedules for sonrotoclax in participants with hematological malignancies. DiseaseChronic Lymphocytic Leukemia CLL SummaryThis study…
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MYDAS-T

MYDAS-T Advancing treatment therapies in Myelodysplasia DiseaseMyelodysplasia SummaryTraditionally, combination therapy has not proven to be effective in Myelodysplasia (MDS) given the increased toxicity of drugs used in combination with standard…
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CML14 (ASCENDANCE) (Closed)

CML14 (ASCENDANCE) A study to assess efficacy of combination therapy with asciminib plus low dose dasatinib in newly diagnosed chronic phase Chronic Myeloid Leukaemia (CML) with high risk genetics DiseaseChronic…
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ALLG NBCR

Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry This study contains no assessments above those that would be offered as standard of care. Information from clinical investigations (including results…
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AMLM26/T3 INTERCEPT

AMLM26/T3 INTERCEPT A multi-arm trial for patients with acute myeloid leukaemia investigating new treatments which target early relapse and changes in disease characteristics – Low-dose cytarabine (LDAC) + Venetoclax DiseaseAcute…
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AMLM26 INTERCEPT

AMLM26 INTERCEPT MRD A multi-arm trial for patients with acute myeloid leukaemia investigating new treatments which target early relapse and changes in disease characteristics – The Master Protocol DiseaseAcute Myeloid…
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AMLM26/T1 INTERCEPT

AMLM26/T1 INTERCEPT AMLM26/T1 INTERCEPT: A multi-arm trial for patients with acute myeloid leukaemia investigating new treatments which target early relapse and changes in disease characteristics – Gilteritinib+ Venetoclax DiseaseAcute Myeloid…
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SOUNDTRACK-B

AZD0486 as Monotherapy in Participants With Relapsed/​Refractory (R/​R) B-cell NHL (SOUNDTRACK-B) This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of AZD0486 monotherapy…
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RIDDLE-M-X (Closed)

Risk Directed front-line therapy for Multiple Myeloma incorporating Selinexor: The RIDDLE-M-X trial Investigating the efficacy of Risk Directed front-line therapy for Multiple Myeloma incorporating Selinexor: The RIDDLE-M-X trial DiseaseMultiple Myeloma…
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PRIMAVERA (D9971C00001)

AZD3470 as Monotherapy and in Combination With Anticancer Agents in Participants With Relapsed/Refractory Haematologic Malignancies. A Modular Phase I/II, Open-label, Multicentre Study to Evaluate the Safety, Tolerability, and Efficacy of…
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BGB-16673-104

BGB-16673-104 A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies. DiseaseB-cell Malignancy Relapsed Cancer Refractory Cancer B-cell…
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SNDX-5613-0700

A Study of Revumenib in R/​R Leukemias Including Those With an MLL/​KMT2A Gene Rearrangement or NPM1 Mutation (AUGMENT-101) A Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in…
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NHL39 POLABEAR (Closed)

A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma (POLAR BEAR) R-MINI-CHOP Versus R-MINI-CHP in…
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TITANium

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/​R B-Cell Malignancies. (TITANium) This is a Phase I/II study…
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LBS-007-CT01 (Closed)

The Safety and Tolerability of LBS-007 in Patients With Relapsed or Resistant Acute Leukaemias A Phase 1/2, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety and Tolerability of…
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JBI-802-102

Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects with Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) with Thrombocytosis. Study to Assess Safety…
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APOLLO AP30CP01

A Study to Investigate APL-4098 Alone and/​or in Combination With Azacitidine in R/​R AML and High-Risk MDS A Phase 1/2 Study to Assess the Safety and Antitumor Activity of APL-4098…
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KRT-232-115

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment (BOREAS) A Phase 2/3 Randomized, Controlled, Open-Label Study of…
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BGB-11417-203

BGB-11417-203 This study will evaluate the safety and efficacy of the BCL2 inhibitor BGB-11417 (sonrotoclax) in participants with relapsed/refractory Waldenström’s Macroglobulinemia (R/R WM) and in combination with zanubrutinib in adult…
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SOUNDTRACK-F1

A Phase III, Multicentre, Randomised, Open-label Study to Compare the Efficacy and Safety of AZD0486 plus Rituximab versus Chemotherapy plus Rituximab in Previously Untreated Participants with Follicular Lymphoma (SOUNDTRACK-F1) This…
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MajesTEC-7

MajesTEC-7 A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab SC and Lenalidomide (Tal-DR) Versus Daratumumab SC, Lenalidomide,…
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CCTL019E2301 (LEDA)

A Randomized, Open-label, Multi-center Phase III Trial Comparing Tisagenlecleucel to Standard of Care in Adult Participants With Relapsed or Refractory Follicular Lymphoma (FL). DiseaseFollicular Lymphoma (FL) SummaryThe purpose of this…
Novartis
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ZE46-0134-002

This is a clinical study aiming to assess pharmacokinetics, pharmacodynamics and preliminary efficacy of ZE46-0134 in patients with FLT3 mutated Relapsed or Refractory Acute Myeloid Leukaemia. DiseaseFLT3 mutated Relapsed or…
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TrAVeRse (Closed)

A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma (TrAVeRse) TrAVeRse is a multicentre, open-label, randomised, Phase II study of AVR in treatment naïve MCL participants. The…
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DR-0201-ONC-001

A Multicenter, Multiple Expansion Cohort, Phase 1 Study Evaluating the Safety and Activity of DR-0201 as Multiple Ascending Doses in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma This is a…
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D7230C00001

D7230C00001 This is a Phase I/II, modular, open-label, multicenter, dose escalation, and dose expansion/optimization study to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary efficacy of AZD0305 in participants…
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87801493LYM1001 (Closed)

87801493LYM1001 A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer DiseaseLymphoma, Non-Hodgkin SummaryThe purpose of this study is to characterize safety and…
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INDEPENDENCE (Closed)

INDEPENDENCE – NO LONGER RECRUITING An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red…
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BGB-21447-101

BGB-21447 Phase 1 Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies DiseaseRelapsed Non-Hodgkin Lymphoma Refractory Non-Hodgkin Lymphoma Relapsed Chronic Lymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Relapsed Follicular Lymphoma…
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AMLM26/T4 INTERCEPT

AMLM26/T4 INTERCEPT A multi-arm trial for patients with acute myeloid leukaemia investigating new treatments which target early relapse and changes in disease characteristics – SNDX5613 DiseaseAcute Myeloid Leukaemia SummaryThe ALLG…
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BGB11417-301 (Closed)

BGB11417-301 Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL) DiseaseCLL SummaryThe main objective of this study is to compare…
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SKYGLO (Closed)

SKYGLO – NO LONGER RECRUITING An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma DiseaseLarge…
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ISB 2001-101

ISB 2001-101 Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma DiseaseRelapsed/Refractory Multiple Myeloma SummaryThis study is a first-in-human, Phase 1, open-label study that will evaluate safety and anti-myeloma activity of…
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GOlDiLOX (Closed)

GOlDiLOX A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure. DiseaseMantle Cell Lymphoma Mantle Cell Lymphoma Refractory SummaryBrief Summary: The goal…
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IKS03-01

IKS03-01 IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas DiseaseB-cell Non-Hodgkin Lymphoma Diffuse Large B Cell Lymphoma Follicular Lymphoma Mantle Cell Lymphoma B-cell Lymphoma SummaryThis first-in-human study will evaluate…
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APTIVATE (Closed)

APTIVATE – NO LONGER RECRUITING A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Tuspetinib (HM43239) in Patients with Relapsed or…
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DREAMM-20 (Closed)

DREAMM-20 A Phase 1/2 Open-label, Multicentre, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, and Clinical Activity of Belantamab as Monotherapy and in Combination With Other Treatments in…
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IMpress_001 (Closed)

IMpress_001 – NO LONGER RECRUITING Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (IMpress) DiseaseMyelodysplastic Syndromes Acute Myeloid Leukemia SummaryThe purpose of this study…
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CTX112 (CRSP-ONC-006)

CTX112 A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies DiseaseB-cell Lymphoma Non-Hodgkin Lymphoma B-cell Malignancy Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) Follicular…
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M20-621 (Closed)

M20-621 – NO LONGER RECRUITING A Phase 3, Randomized, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination With R-CHOP Compared to R-CHOP in Subjects With Newly Diagnosed…
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MagnetisMM-5 (Closed)

MagnetisMM-5 – NO LONGER RECRUITING Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/​Refractory Multiple Myeloma (MAGNETISMM-5) DiseaseMultiple Myeloma SummaryBrief…
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PRT2527-02 (Closed)

PRT2527-02 A Study of PRT2527 in Participants With Relapsed/Refractory Hematologic Malignancies DiseaseAggressive B-Cell Non-Hodgkin’s Lymphoma Aggressive B-Cell NHL Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Mantle Cell Lymphoma (MCL) Richter’s Syndrome SummaryThis…
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DR-01-ONC-001 (Closed)

DR-01-ONC-001 – NO LONGER RECRUITING A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas DiseaseLGLL – Large Granular Lymphocytic Leukemia Primary Cutaneous T-Cell Lymphoma –…
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LOXO-BTK-20019 (Closed)

LOXO-BTK-20019 – NO LONGER RECRUITING Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321) DiseaseLymphoma, Mantle-Cell SummaryThis is a Phase 3…
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80948543LYM1001

80948543LYM1001 A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) DiseaseLymphoma, Non-Hodgkin Leukemia, Lymphocytic,…
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BGB-11417-103

BGB-11417-103 A Study of BGB-11417 in Participants With Myeloid Malignancies DiseaseAcute Myeloid Leukemia Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasm SummaryThe study will determine the safety, tolerability, recommended Phase 2 dose (RP2D) and…
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M20-638 (Closed)

M20-638 – NO LONGER RECRUITING Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma (EPCORE…
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MajesTEC-9 (Closed)

MajesTEC-9 A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-9) DiseaseRelapsed or Refractory Multiple Myeloma SummaryThe…
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SLN124-004

SLN124-004 Phase 1/2 Study With an Open-label Dose Escalation Phase Followed by a Randomized, Double-blind Phase of SLN124 in Patients With Polycythemia Vera DiseasePolycythemia Vera SummaryThis is a Phase 1/2,…
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D8231C00001 (Closed)

D8231C00001 – NO LONGER RECRUITING AZD4573 as Monotherapy or in Combinations With Anti-cancer Agents in Patients With r/r PTCL or r/r cHL DiseaseRelapsed/Refractory Peripheral T-cell Lymphoma Relapsed/Refractory Classical Hodgkins Lymphoma…
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MAJIC (Closed)

MAJIC – NO LONGER RECRUITING A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic…
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DZ2022B0002 (Closed)

DZ2022B0002 A Phase 1, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Efficacy of DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (B-NHL) DiseaseNon-Hodgkin Lymphoma…
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AMLM26/T5 INTERCEPT

AMLM26/T5 INTERCEPT A multi-arm trial for patients with acute myeloid leukaemia investigating new treatments which target early relapse and changes in disease characteristics – MBG453 OR MBG453 and Azacitidine DiseaseLeukaemia…
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BLOCK PCNSL (NHL32) (Closed)

BLOCK PCNSL (NHL32) An ALLG Phase II study of pembrolizumab checkpoint blockade following chemoimmunotherapy for primary central nervous system lymphoma DiseaseLymphoma (non Hodgkin’s lymphoma) SummaryThe purpose of this study is…
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SUCCESSOR-1 (CA057-001) (Closed)

SUCCESSOR-1 (CA057-001) A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing CC-92480, Bortezomib and Dexamethasone (480Vd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma…
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ASTX660-03 (Closed)

ASTX660-03 – NO LONGER RECRUITING A Study of Tolinapant in Combination With Oral Decitabine/Cedazuridine and Oral Decitabine/Cedazuridine Alone in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma (R/R PTCL) DiseaseRelapsed/Refractory Peripheral T-cell…
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BELLWAVE (MK-1026-003)

Bellwave (MK-1026-003) A Phase 2 Study to Evaluate the Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies DiseaseHematologic Malignancies SummaryThe purpose of this study is to evaluate…
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NHL35: ALLG-PACIFIC

NHL35: ALLG-PACIFIC An open label phase 2 study of Pembrolizumab And Chemo-Immunotherapy as FIrst-line therapy for primary mediastinal B-Cell lymphoma DiseaseB-Cell Lymphoma Summary open label phase II study of R-CHOP…
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Zentalis ZN-d5-003 (Closed)

Zentalis ZN-d5-003 – NO LONGER RECRUITING This is a single arm, Open-Label, Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis. Disease Amyloidosis…
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SNDX-5613-0700 (Closed)

SNDX-5613-0700 – NO LONGER RECRUITING A Study of SNDX-5613 in R/R Leukemias Including Those With an MLLr/KMT2A Gene Rearrangement or NPM1 Mutation (AUGMENT-101) Disease Acute Myeloid Leukemia Acute Lymphoblastic Leukemia…
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GB5121-2101: STAR-CNS (Closed)

GB5121-2101: STAR-CNS – NO LONGER RECRUITING The STAR CNS trial is a 3-part study, comprising a phase 1b dose escalation, dose expansion, and a phase 2, to assess the safety,…
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EZH-302 (Closed)

EZH-302 A Phase 1b/3 Double Blind Randomized, Active-Controlled, 3-stage, Biomarker Adaptive Study of Tazemetostat or Placebo in Combination with Lenalidomide Plus Rituximab in Subjects with Relapsed/Refractory Follicular Lymphoma DiseaseRelapsed/Refractory Follicular…
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ESCALADE (Closed)

A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) (ESCALADE)
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COALITION (Closed)

A multicentre, parallel arm, open-label trial of frontline R-CHOP/Pola-RCHP and glofitamab in younger, higher risk patients with…
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LOXO-BTK-20022 (Closed)

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously…
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BGB-16673-101

A Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients…
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STARGLO (Closed)

STARGLO – NO LONGER RECRUITING Starglo is a phase III, open-label, multicenter, randomized study evaluating the efficacy and safety of glofitamab in combination with gemcitabine plus oxaliplatin versus rituximab in…
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DREAMM 8 (Closed)

A Phase III, Multicenter, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in…
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FRONTMIND (Closed)

A Phase 3, multicenter, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of tafasitamab plus lenalidomide…
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Epcoritamab (GCT3013-02)

A Phase 1b/2, Open-Label Trial to Assess the Safety and Preliminary Efficacy of Epcoritamab (GEN3013; DuoBody®-CD3xCD20) in…
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TARMAC (Closed)

A Phase II, Open-Label, Single Arm Trial to Assess the Efficacy and Safety of the Combination of…
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64264681LYM1002 (Closed)

A Phase 1b, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64264681 in Combination with JNJ-67856633…
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D8230C00002 (Closed)

A Modular Phase I/II, Open-label, Multicentre Study to Assess AZD4573 in Novel Combinations With Anti-cancer Agents in…
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AMLM25 (Closed)

An ALLG Phase 2 study to Investigate Novel Triplets to Extend Remission with Venetoclax in Elderly Acute…
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IGM-2323 (Closed)

A Phase 1 Open-label, Multicenter Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of IGM-2323 in…
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ENHANCE (Closed)

A Randomized, Double Blind, Multicenter Study Comparing Magrolimab in Combination with Azacitidine versus Azacitidine plus Placebo in…
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NHL33 (Closed)

NHL33 – NO LONGER RECRUITING An ALLG Window Study of Acalabrutinib plus Rituximab followed by Cytarabine, Oxaliplatin, Dexamethasone and Rutixumab (R-DHAOx) + Autologous Stem Cell Transplant (ASCT) in newly diagnosed…
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DREAMM 3 (Closed)

A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Single Agent Belantamab Mafodotin…
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AMLM22/D2

The International Acute myeloid leukaemia (AML) Platform Consortium (IAPC) trial is a randomised, multi-arm study platform to…
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ITHACA (Closed)

A Phase 3 Randomized, Open Label, Multicenter Study of Isatuximab (SAR650984) in Combination With Lenalidomide and Dexamethasone…
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GCT-3013-01 (Closed)

A Phase 1/2, Open-Label, Dose-Escalation Trial of GEN3013 in Patients with Relapsed, Progressive or Refractory B-Cell Lymphoma
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BGB-3111-113 (Closed)

A Drug–Drug Interaction Study of Zanubrutinib with Moderate and Strong CYP3A Inhibitors in Patients with B-Cell Malignancies
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MALT-1 (Closed)

A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-67856633, an Inhibitor of…
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UNITY-NHL (Closed)

A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab +…
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GO29781 (Closed)

An open-label, multicenter, phase I/IB trial evaluating the safety and pharmacokinetics of escalating doses of BTCT4465A as…
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FORMA (Closed)

A Phase 1/2 study evaluating the safety, efficacy, pharmacokinetics and pharmacodynamics of FT-2102 with or without azacitidine…
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PLIMATH (Closed)

A Phase II Study to Determine Pembrolizumab as Frontline Treatment of Patients With Hodgkin Lymphoma (PLIMATH)
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GMI-1271-301 (Closed)

A Phase III Randomized, Double-Blind Trial to Evaluate the Efficacy of Uproleselan Administered with Chemotherapy versus Chemotherapy…
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DREAMM6 (Closed)

To Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-drug Conjugate, GSK2857916 Administered in Combination With Lenalidomide…
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ACE-CL-311 (Closed)

A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in…
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LOXO-BTK-18001 (Closed)

A Phase 1/2 Study of Oral LOXO-305 in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma…
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LEVERAGE (Closed)

Study of Lenalidomide, Venetoclax and Obinutuzumab in Patients With Treatment Naïve Follicular Lymphoma
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ASSURE (Closed)

ASSURE is a Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib in Subjects with Chronic Lymphocytic Leukaemia.
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BGB-11417-101

A Phase 1/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417 in Patients with Mature…
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